Gaelen Hess

Position title: Assistant Professor

Email: ghess3@wisc.edu

Lab Website
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Dr. Gaelen Hess is an Assistant Professor within the Department of Biomolecular Chemistry and Center for Human Genomics and Precision Medicine.

Research Interests

With the emerging appreciation of precision medicine, the link of genetic and epigenetic perturbations to their phenotypes is vital. With the advent of CRISPR-mediated genome editing and high-throughput sequencing, we can systematically perturb the genome and quantitatively measure how these alterations affect cellular fitness and function. In the Hess lab, we are interested in both developing and applying these and other functional genomics technologies to address critical biological questions and improve human health. Using these cutting-edge genomics tools, we focus on two primary research goals: (1) identifying genetic factors that alter disease risk and therapeutic response by regulating genome instability and DNA repair and (2) discovering functional biomolecules, such as peptides, for engineering mammalian cells.

Gaelen Hess Publications

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