Dr. Gaelen Hess is an Assistant Professor within the Department of Biomolecular Chemistry and Center for Human Genomics and Precision Medicine.
Research Interests
With the emerging appreciation of precision medicine, the link of genetic and epigenetic perturbations to their phenotypes is vital. With the advent of CRISPR-mediated genome editing and high-throughput sequencing, we can systematically perturb the genome and quantitatively measure how these alterations affect cellular fitness and function. In the Hess lab, we are interested in both developing and applying these and other functional genomics technologies to address critical biological questions and improve human health. Using these cutting-edge genomics tools, we focus on two primary research goals: (1) identifying genetic factors that alter disease risk and therapeutic response by regulating genome instability and DNA repair and (2) discovering functional biomolecules, such as peptides, for engineering mammalian cells.
Gaelen Hess Publications
- Development of compact transcriptional effectors using high-throughput measurements in diverse contexts
November 2, 2024 - A High-Throughput Screen for Antiproliferative Peptides in Mammalian Cells Identifies Key Transcription Factor Families
October 19, 2024 - Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform
September 30, 2022 - Phage Particles of Controlled Length and Genome for <em>In Vivo</em> Targeted Glioblastoma Imaging and Therapeutic Delivery
July 13, 2022 - Pathogenic or benign?
May 16, 2022 - Roadmap for the use of base editors to decipher drug mechanism of action
September 21, 2021 - Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
January 26, 2021 - High-Throughput Discovery and Characterization of Human Transcriptional Effectors
December 16, 2020 - LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP
November 10, 2020 - Metabolic precision labeling enables selective probing of O-linked <em>N</em>-acetylgalactosamine glycosylationSeptember 29, 2020
- Transcriptomic signatures across human tissues identify functional rare genetic variation
September 11, 2020 - Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins
November 2, 2019 - Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements
September 8, 2019 - SLC19A1 Is an Importer of the Immunotransmitter cGAMP
May 26, 2019