Position title: Assistant Professor
As a physician-scientist, my goal is to improve the lives of cancer patients through effective therapeutic strategies. There remains a great need in precision oncology to define distinct patient populations for primary liver and pancreatic cancers. Patient-derived organotypic models provide an individual culture to improve disease modeling for mechanistic and therapeutic studies. Using a combination of therapeutic screens, novel co-culture models, and xenograft studies, my laboratory works within the complexities of patient-derived models to predict and refine therapeutic strategies. The ultimate goal is to develop early phase clinical trials for clinical impact at the University of Wisconsin Carbone Cancer Center.
My laboratory is focused on the translation of patient-derived organoid models of primary liver and pancreatic cancers to overcome mechanisms of molecular heterogeneity in conferring clinically significant resistance. Using a combination of mechanistic studies in organoids and animal models, we aim to develop novel therapeutic strategies that predict mechanisms of resistance at the level of transcriptional regulation.